Oral delivery of protein drugs is an attractive route of administration due to its convenience
for repeated dosing and good patient compliance. However, currently oral protein …

Drug degradation at low pH and rapid clearance from intestinal absorption sites are the
main factors limiting the development of oral macromolecular delivery systems. Based on …

Oral administration of insulin faces multiple biological challenges, such as varied digestive
environments, mucin exclusion, and low epithelial cells' absorption. In the present study, a …

In the present study, we developed novel insulin-loaded hyaluronic acid (HA) nanoparticles
for insulin delivery. The insulin-loaded HA nanoparticles were prepared by reverse …

Abstract Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an
ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan …

A variety of approaches have been studied in the past to overcome the problems
encountered with the oral delivery of insulin, but with little success. In this study, self …

The potential of nanoparticles (NPs) to overcome the barriers for oral delivery of protein
drugs have led to the development of platforms capable of improving their bioavailability …

Oral administration is an ideal alternative for drug delivery due to its convenience and safety.
However, oral protein delivery is limited by biological barriers such as the mucus barrier and …

Despite advances in drug-delivery technologies, successful oral administration of protein
drugs remains an elusive challenge. When protein drugs are administered orally, they can …

The oral route is considered to be the most convenient and comfortable means of drug
administration for patients. Nevertheless, oral administration of hydrophilic macromolecules …