As a common environmental pollutant, cadmium (Cd) causes damage to many organs of the
body. Gap junction intercellular communication (GJIC) represents one of the most important …

Cadmium (Cd) is known to induce hepatotoxicity, yet the underlying mechanism of how this
occurs is not fully understood. In this study, Cd-induced apoptosis was demonstrated in rat …

Cadmium is an important environmental pollutant that poses a serious threat to the health of
humans and animals. A large number of studies have shown that the liver is one of the …

Cadmium (Cd) is an environmental pollutant of increasing importance, due to
industrialization, smoking, and the lack of effective therapy for Cd poisoning. The general …

It is known that cadmium (Cd) induces cytotoxicity in hepatocytes; however, the underlying
mechanism is unclear. Here, we studied the molecular mechanisms of Cd-induced …

Cadmium (Cd), a toxic heavy metal, is known to induce renal toxicity by primarily targeting at
renal proximal tubule. Endoplasmic reticulum (ER) stress and gap junctional intercellular …

Gap junctions mediate direct communication between cells; however, toxicological cascade
triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions …

Gap junction protein connexin 43 (Cx43) plays a critical role in gap junction communication
in rat hepatocytes. However, those located between hepatocytes are easily internalized …

Although reactive oxygen species (ROS) have been implicated in cadmium (Cd)-induced
hepatotoxicity, the role of ROS in this pathway remains unclear. Therefore, we attempted to …

Cadmium (Cd) is a common heavy metal that is highly toxic to the liver, however, the exact
mechanism underlying this damage accompanied by apoptosis has not been thoroughly …