Most eukaryotic mRNAs and different non‐coding RNAs undergo a form of 3′ end
processing known as polyadenylation. Polyadenylation machinery is present in almost all …

Poly (A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs,
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …

During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐
end processing reaction in which the pre‐mRNA is cleaved and released from the …

There has been rapid progress over the past 3-4 years in elucidating the functions of the
poly (A) tail in both eukaryotes and prokaryotes. As a large number of previous experiments …

Post-transcriptional addition of poly (A) tails to the 3′ end of RNA is one of the fundamental
events controlling the functionality and fate of RNA in all kingdoms of life. Although an …

In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies
have suggested that polyadenylate tail may play a vital role in such a system. The poly (A) …

The abundance of messenger RNA (mRNA) is one of the major determinants of protein
synthesis. As such, factors that influence mRNA stability often contribute to gene regulation …

Message RNA poly (A) tails are vital for their function and regulation. However, the full-
length sequence of mRNA isoforms with their poly (A) tails remains undetermined. Here, we …

Polyadenylation at the 3′ ends of mRNAs is critical to the translation and stability of the
messages. Recently determined structures of poly (A) polymerase, U1A and domains of the …

Polyadenylation is a posttranscriptional modification present throughout all the kingdoms of
life with important roles in regulation of RNA stability, translation, and quality control …