Colorectal cancer (CRC) is estimated to rank as the second reason for cancer-related
deaths, and the prognosis of CRC patients remains unsatisfactory. Numerous studies on …

Accumulative studies revealed that E3 ubiquitin ligases have important roles in colorectal
carcinogenesis. The pathogenic mechanisms of colorectal cancer (CRC) initiation and …

Gastric cancer (GC) is one of the pernicious gastrointestinal tumors with extraordinarily high
incidence and mortality. Ubiquitination modification of cellular signaling proteins has been …

Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …

The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial
signaling pathways implicated in tumorigenesis is presently an area of intense research and …

HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is
composed of six members classified by size into large (HERC1 and HERC2) and small …

Ubiquitination-mediated proteolysis or regulation of proteins, ultimately executed by E3
ubiquitin ligases, control a wide array of cellular processes, including transcription, cell …

In the ubiquitylation system, E3 ubiquitin ligases play a key role in determining substrate
specificity and catalyzing the transfer of ubiquitin from E2 enzymes to the substrate. Growing …

Ubiquitination, a post-translational modification that involves a covalent attachment of
ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end …