Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
X Meng, G Navoly, O Giannakopoulou, D Levey… - bioRxiv, 2022 - biorxiv.org
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
[HTML][HTML] Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature Genetics, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
GWAS of depression phenotypes in the million veteran program and meta-analysis in more than 1.2 million participants yields 178 independent risk loci
We report a large meta-analysis of depression using data from the Million Veteran Program
(MVP), 23andMe Inc., UK Biobank, and FinnGen; including individuals of European ancestry …
(MVP), 23andMe Inc., UK Biobank, and FinnGen; including individuals of European ancestry …
Genome-wide study of major depression in 685,808 diverse individuals identifies 697 independent associations, infers causal neuronal subtypes and biological …
MJ Adams… - medRxiv, 2024 - medrxiv.org
In a genome-wide association study (GWAS) meta-analysis of 685,808 individuals with
major depression (MD) and 4,364,225 controls from 29 countries and across diverse and …
major depression (MD) and 4,364,225 controls from 29 countries and across diverse and …
[HTML][HTML] Novel loci for major depression identified by genome-wide association study of STAR* D and meta-analysis of three studies
We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in
1,221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) …
1,221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …
used data from individuals of European descent. This limits the understanding of the …
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three …
We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in
1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) …
1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) …
Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression
Y Li, X Dang, R Chen, J Wang, S Li, BL Mitchell… - MedRxiv, 2023 - medrxiv.org
Deciphering the genetic architecture of depression is pivotal for characterizing the
associated pathophysiological processes and development of new therapeutics. Here we …
associated pathophysiological processes and development of new therapeutics. Here we …
Minimal phenotyping yields GWAS hits of reduced specificity for major depression
Background Minimal phenotyping refers to the reliance on self-reported responses to one or
two questions for disease case identification instead of full diagnostic criteria. This strategy …
two questions for disease case identification instead of full diagnostic criteria. This strategy …
[HTML][HTML] A novel strategy for clustering major depression individuals using whole-genome sequencing variant data
Major depressive disorder (MDD) is highly prevalent, resulting in an exceedingly high
disease burden. The identification of generic risk factors could lead to advance prevention …
disease burden. The identification of generic risk factors could lead to advance prevention …