OBJECTIVES: Endoscopy-negative gastroesophageal reflux disease (GERD) lacks
objective markers of disease severity. Evaluation of therapies for GERD must therefore rely …

Background: Medical treatments for gastro‐oesophageal reflux disease (GERD) vary in their
ability to completely resolve heartburn and other symptoms. Although GERD reduces health …

Objective. A pooled analysis, using data from three prospective, randomized, double-blind,
placebo-controlled, clinical studies, was undertaken to determine the relationship between …

OBJECTIVE: Esophago-gastro-duodenoscopy (EGD) is frequently performed in patients with
heartburn. However, the benefit of an EGD is unclear. The objective is to determine the …

Severity and frequency of gastroesophageal reflux disease (GERD) related symptoms are
associated with impaired health-related quality of life (HRQL). This study evaluated the …

Background Heartburn that persists despite proton-pump inhibitor (PPI) treatment is a
frequent clinical problem with multiple potential causes. Treatments for PPI-refractory …

Heartburn is among the most common gastrointestinal symptoms presenting to both
generalist physicians and gastroenterologists. Heartburn that does not respond to traditional …

Key Clinical Points Gastroesophageal Reflux Disease Patients with heartburn and
symptoms such as dysphagia, odynophagia, weight loss, anorexia, gastrointestinal …

This study reports the reliability and validity of the distress subscale of the GERD Symptom
Assessment Scale (GSAS) and the acute SF-36 Health Survey in a clinical trial setting …

BACKGROUND: Failure of proton pump inhibitor (PPI) treatment in patients with heartburn is
very common. Because endoscopy is easily accessible, it is commonly used as the first …