Migraine is a primary headache disorder characterized by unilateral throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the
migraine attacks are sporadic; however, some individuals experience a gradual increase in …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

The potential involvement of neurogenic inflammation in the pathogenesis of the migraine
headache and the inhibition of this mechanism as a possible mode of action of antimigraine …

The role of neuroinflammation in the pathophysiology of migraines is increasingly being
recognized, and cytokines, which are important endogenous substances involved in …

Here, in this review, we present our hypothesis of the migraine pathogenesis. We believe
that migraine attacks derive from a top-down dysfunctional process that initiates in a …

Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …