Migraine is a complex and debilitating neurological disease that affects 15% of the
population worldwide. It is defined by the presence of recurrent severe attacks of disabling …

Background A system of lymphatic vessels has been recently characterized in the meninges,
with a postulated role in 'cleaning'of the brain via cerebro-spinal fluid drainage. As meninges …

Objective.—The goal of this study was to investigate neuronal–glial cell signaling in
trigeminal ganglia under basal and inflammatory conditions using an in vivo model of …

Migraine is a complicated neurological disorder affecting 6% of men and 18% of women
worldwide. Various mechanisms, including neuroinflammation, oxidative stress, altered …

Understanding the mechanisms of migraine remains challenging as migraine is not a static
disorder, and even in its episodic form migraine remains an “evolutive” chronic condition …

Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

Migraine headaches are often precipitated by stress and seem to involve neurogenic
inflammation (NI) of the dura mater associated with the sensation of throbbing pain …

Migraine attacks are triggered by a variety of conditions including endogenous and
exogenous factors. Evidence suggests that activation and sensitization of primary afferent …

Background: There has been a protracted effort to identify reliable targets for migraine. It is
believed that each year, hundreds of millions of individuals worldwide suffer from migraines …

Compelling evidence indicates that dural afferent sensitization initiates migraine pain.
Furthermore, mechanisms of dural afferent sensitization may be unique given that ion …