Although absence of interleukin-7 (IL-7) signaling completely abrogates T and B
lymphopoiesis in mice, patients with severe combined immunodeficiency caused by …

IL-7 is critical for murine T and B cell development and survival and plays a significant role in
lymphoblastic leukemia in both humans and mice. We evaluated the role of the IL-7Rα Tyr …

IL-7 is critical for B cell production in adult mice; however, its role in human B lymphopoiesis
is controversial. One challenge was the inability to differentiate human cord blood (CB) or …

Interleukin-7 (IL-7) plays several important roles during B cell development including aiding
in; the specification and commitment of cells to the B lineage, the proliferation and survival of …

Cytokine receptor signals have been suggested to stimulate cell differentiation during
hemato/lymphopoiesis. Such action, however, has not been clearly demonstrated. Here, we …

Mice lacking functional IL-7 or IL-7Rα genes are severely deficient in developing
thymocytes, T cells, and B cells. IL-7 and IL-7 receptor functions are believed to result in …

IL-7 is an important cytokine for lymphocyte differentiation. Similar to what occurs in vivo,
human CD19+ cells developing in human/murine xenogeneic cultures show differential …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Although interleukin-7 (IL-7) is essential for human and murine lymphopoiesis and
homeostasis, clear disparities between these species regarding the role of IL-7 during B-cell …

Little is known about the signals that promote early B lineage differentiation from common
lymphoid progenitors (CLPs). Using a stromal-free culture system, we show that interleukin …