Messenger RNA (mRNA)-based cancer vaccine has become a popular approach for
developing personalized and effective antitumor immunotherapy. To achieve robust …

Intracellular delivery of messenger RNA (mRNA)-based cancer vaccine has shown great
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor
antigens into the body to activate specific anti-tumor immune responses. Along with the …

Vaccines hold tremendous potential for cancer immunotherapy by treating the immune
system. Subunit vaccines, including molecular adjuvants and cancer-associated antigens or …

Cancer vaccines combined with immune checkpoint blockades (ICB) represent great
potential application, yet the insufficient tumor antigen presentation and immature dendritic …

Highlights•mRNA nanotherapeutics enable significant advances in cancer immunotherapy.•
mRNA nanoformulation allows modulation of immune cells engaged in antitumor …

Use of mRNA-based vaccines for tumour immunotherapy has gained increasing attention in
recent years. A growing number of studies applying nanomedicine concepts to mRNA …

For efficient cancer vaccines, the antitumor function largely relies on cytotoxic T cells, whose
activation can be effectively induced via antigen-encoding mRNA, making mRNA-based …

The approved worldwide use of two messenger RNA (mRNA) vaccines (BNT162b2 and
mRNA-1273) in late 2020 has proven the remarkable success of mRNA therapeutics …

The success of lipid nanoparticles (LNPs) in treating COVID-19 promotes further research of
mRNA vaccines for cancer vaccination. Aiming at overcoming the constraints of currently …