Adequate and continuous expression of genes lies beneath all cellular activities. Due to that,
the complex and dynamic network of gene regulation is a critical component of the cellular …

Purpose: The term 'epigenetics' refers to heritable changes in gene expression or phenotype
that occur without changes to the underlying DNA sequence. There are three mechanisms of …

The role of epigenetics in aging and age-related diseases is a key issue in molecular
physiology and medicine because certain epigenetic factors are thought to mediate, at least …

This review aims to provide a summary of current concepts of ageing in relation to the
musculoskeletal system, highlighting recent advances in the understanding of the …

Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an
absolute consequence of joint mechanical use (wear and tear); rather recent data …

What molecular mechanisms regulate cell senescence and organism aging? Why aging
processes show different onset, duration, and intensity in different subjects? Why the normal …

The interest in exploring the role of epigenetics in the aging process has grown
tremendously in recent years as demonstrated, in part, by the steadily increasing number of …

Growth and development of higher organisms are regulated by the orchestrated change of
epigenetic marks over time. In addition, there is also an epigenetic variation without any …

The identification of genomic loci that are associated with osteoarthritis (OA) has provided a
starting point for understanding how genetic variation activates catabolic processes in the …

Aging is a progressive and complicated bioprocess with overall decline in physiological
function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older …