[HTML][HTML] A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans

FL Mayer, E Sánchez-León, JW Kronstad - Microbial Cell, 2018 - ncbi.nlm.nih.gov
Pathogenic microorganisms employ specialized virulence factors to cause disease. Biofilm
formation and the production of a polysaccharide capsule are two important virulence factors …

Analysis of the protein kinase A-regulated proteome of Cryptococcus neoformans identifies a role for the ubiquitin-proteasome pathway in capsule formation

JMH Geddes, M Caza, D Croll, N Stoynov, LJ Foster… - MBio, 2016 - Am Soc Microbiol
The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening
meningitis in immunocompromised individuals. The expression of virulence factors …

Cross talk between the cell wall integrity and cyclic AMP/protein kinase A pathways in Cryptococcus neoformans

MJ Donlin, R Upadhya, KJ Gerik, W Lam… - MBio, 2014 - Am Soc Microbiol
Cryptococcus neoformans is a fungal pathogen of immunocompromised people that causes
fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C …

Phospholipase B is critical for Cryptococcus neoformans survival in the central nervous system

MF Hamed, GRS Araújo, ME Munzen… - Mbio, 2023 - Am Soc Microbiol
Cryptococcus neoformans (Cn) is an opportunistic, encapsulated, yeast-like fungus that
causes severe meningoencephalitis, especially in countries with high HIV prevalence. In …

[HTML][HTML] Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans

KT Lee, YS So, DH Yang, KW Jung, J Choi… - Nature …, 2016 - nature.com
Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature …

[HTML][HTML] The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System

L Aslanyan, DA Sanchez, S Valdebenito, EA Eugenin… - Journal of Fungi, 2017 - mdpi.com
Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life
threatening meningoencephalitis in patients with impaired immunity. This microbe primarily …

[HTML][HTML] Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule

TR O'Meara, D Norton, MS Price, C Hay… - PLoS …, 2010 - journals.plos.org
Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within
various tissues in order to establish a human infection. We have identified the C …

Inositol metabolism regulates capsule structure and virulence in the human pathogen Cryptococcus neoformans

Y Wang, M Wear, G Kohli, R Vij, C Giamberardino… - Mbio, 2021 - Am Soc Microbiol
The environmental yeast Cryptococcus neoformans is the most common cause of deadly
fungal meningitis in primarily immunocompromised populations. A number of factors …

[HTML][HTML] Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans

KT Lee, J Hong, DG Lee, M Lee, S Cha, YG Lim… - Nature …, 2020 - nature.com
Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …

Unraveling capsule biosynthesis and signaling networks in Cryptococcus neoformans

EH Jang, JS Kim, SR Yu, YS Bahn - Microbiology spectrum, 2022 - Am Soc Microbiol
The polysaccharide capsule of Cryptococcus neoformans—an opportunistic basidiomycete
pathogen and the major etiological agent of fungal meningoencephalitis—is a key virulence …