[HTML][HTML] A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans
FL Mayer, E Sánchez-León, JW Kronstad - Microbial Cell, 2018 - ncbi.nlm.nih.gov
Pathogenic microorganisms employ specialized virulence factors to cause disease. Biofilm
formation and the production of a polysaccharide capsule are two important virulence factors …
formation and the production of a polysaccharide capsule are two important virulence factors …
Analysis of the protein kinase A-regulated proteome of Cryptococcus neoformans identifies a role for the ubiquitin-proteasome pathway in capsule formation
The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening
meningitis in immunocompromised individuals. The expression of virulence factors …
meningitis in immunocompromised individuals. The expression of virulence factors …
Cross talk between the cell wall integrity and cyclic AMP/protein kinase A pathways in Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen of immunocompromised people that causes
fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C …
fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C …
Phospholipase B is critical for Cryptococcus neoformans survival in the central nervous system
MF Hamed, GRS Araújo, ME Munzen… - Mbio, 2023 - Am Soc Microbiol
Cryptococcus neoformans (Cn) is an opportunistic, encapsulated, yeast-like fungus that
causes severe meningoencephalitis, especially in countries with high HIV prevalence. In …
causes severe meningoencephalitis, especially in countries with high HIV prevalence. In …
[HTML][HTML] Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans
Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature …
however, treatment options remain limited. Here we report the construction of 264 signature …
[HTML][HTML] The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System
L Aslanyan, DA Sanchez, S Valdebenito, EA Eugenin… - Journal of Fungi, 2017 - mdpi.com
Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life
threatening meningoencephalitis in patients with impaired immunity. This microbe primarily …
threatening meningoencephalitis in patients with impaired immunity. This microbe primarily …
[HTML][HTML] Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule
TR O'Meara, D Norton, MS Price, C Hay… - PLoS …, 2010 - journals.plos.org
Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within
various tissues in order to establish a human infection. We have identified the C …
various tissues in order to establish a human infection. We have identified the C …
Inositol metabolism regulates capsule structure and virulence in the human pathogen Cryptococcus neoformans
The environmental yeast Cryptococcus neoformans is the most common cause of deadly
fungal meningitis in primarily immunocompromised populations. A number of factors …
fungal meningitis in primarily immunocompromised populations. A number of factors …
[HTML][HTML] Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans
Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …
Unraveling capsule biosynthesis and signaling networks in Cryptococcus neoformans
EH Jang, JS Kim, SR Yu, YS Bahn - Microbiology spectrum, 2022 - Am Soc Microbiol
The polysaccharide capsule of Cryptococcus neoformans—an opportunistic basidiomycete
pathogen and the major etiological agent of fungal meningoencephalitis—is a key virulence …
pathogen and the major etiological agent of fungal meningoencephalitis—is a key virulence …