Administration of resuscitation volumes far beyond the estimates established by burn-body
weight resuscitation formulas has been well documented. The reasons behind this increase …

The effect of analgesia on physiological systems has received little attention in trauma
research. Our aim was to examine the effect of two different analgesics, buprenorphine and …

Introduction Despite concerns about long-term dependence, opioids remain the mainstay of
treatment for acute pain from traumatic injuries. Additionally, early pain management has …

Editor's Note: You are reading the 47th installment of Annals of Emergency Medicine
Journal Club. This Journal Club refers to the article by Motov et al 1 published in the …

We read the recent CMAJ article on ketamine for the treatment of acute pain by Silverstein
and colleagues with great interest. 1 They note that low-dose ketamine is an effective …

Introduction: The recreational use of fentanyl in combination with xylazine (ie,“tranq-dope”)
represents a rapidly emerging public health threat characterized by significant toxicity and …

Background Tactical Combat Casualty Care guidelines for hemorrhage recommend
resuscitation to systolic blood pressure (SBP) of 85±5 mm Hg during prehospital care …

Background Ketamine, as an opium alternative, has been proposed for pain relief in the
emergency department (ED). Objectives This study was carried out to compare low dose …

We evaluated the relationship of either the infusion time or the plasma morphine
concentrations on the magnitude of acute tolerance to morphine analgesia. Male New …

Background. Fentanyl has several potential advantages for out-of-hospital analgesia,
including rapid onset, short duration, and less histamine release. Objective. To compare the …