[HTML][HTML] Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization

SX Xu, KJ Kasper, JJ Zeppa, JK McCormick - Toxins, 2015 - mdpi.com
Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T
cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system …

[HTML][HTML] Manipulation of innate and adaptive immunity by staphylococcal superantigens

SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production

SW Tuffs, MI Goncheva, SX Xu… - Proceedings of the …, 2022 - National Acad Sciences
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Superantigens Subvert the Neutrophil Response To Promote Abscess Formation and Enhance Staphylococcus aureus Survival In Vivo

SX Xu, KJ Gilmore, PA Szabo, JJ Zeppa… - Infection and …, 2014 - Am Soc Microbiol
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating
toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can …

[HTML][HTML] Staphylococcal superantigens in colonization and disease

SX Xu, JK McCormick - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be
produced by only a few bacterial pathogens, including Staphylococcus aureus. More than …

Population analysis of Staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia

M Vrieling, SW Tuffs, G Yebra, MY van Smoorenburg… - Mbio, 2020 - Am Soc Microbiol
Staphylococcal superantigens (SAgs) are a family of secreted toxins that stimulate T cell
activation and are associated with an array of diseases in humans and livestock. Most SAgs …

Staphylococcal superantigen super-domains in immune evasion

R Langley, D Patel, N Jackson, F Clow… - Critical Reviews™ in …, 2010 - dl.begellhouse.com
Staphylococcus aureus is a robust pathogen that is capable of growing in virtually any part
of the human body, and can also survive and grow in many other species. S. aureus remains …

[HTML][HTML] Superantigens of a superbug: Major culprits of Staphylococcus aureus disease?

MJ Aman - Virulence, 2017 - Taylor & Francis
Infections with multidrug resistant (MDR) bacteria represent a major challenge for public
health. Methicillin resistant S. aureus (MRSA) is one of the leading causes of hospital and …

[HTML][HTML] Bacterial Superantigens Promote Acute Nasopharyngeal Infection by Streptococcus pyogenes in a Human MHC Class II-Dependent Manner

KJ Kasper, JJ Zeppa, AT Wakabayashi, SX Xu… - PLoS …, 2014 - journals.plos.org
Establishing the genetic determinants of niche adaptation by microbial pathogens to specific
hosts is important for the management and control of infectious disease. Streptococcus …

Novel insights into the immune response to bacterial T cell superantigens

SW Tuffs, K Dufresne, A Rishi, NR Walton… - Nature Reviews …, 2024 - nature.com
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …