Lipid overload of the mitochondria is linked to the development of insulin resistance in
skeletal muscle which may be a contributing factor to the progression of type 2 diabetes …

Background Type 2 diabetes mellitus and muscle insulin resistance have been associated
with reduced capacity of skeletal muscle mitochondria, possibly as a result of increased …

Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

In obesity, skeletal muscle mitochondrial activity changes to cope with increased nutrient
availability. Autophagy has been proposed as an essential mechanism involved in the …

High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR)
and type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is …

The tissue-specific role of mitochondrial respiratory capacity in the development of insulin
resistance and type 2 diabetes is unclear. We determined mitochondrial function in glycolytic …

It has been suggested that skeletal muscle mitochondria play a key role in high fat (HF) diet
induced insulin resistance (IR). Two opposite views are debated on mechanisms by which …

New Findings What is the topic of this review? The review covers basic knowledge about the
role of mitochondria in the homeostatic function of adipose tissue. It also provide a …

Skeletal muscle mitochondrial protein synthesis is regulated in part by insulin. The
development of insulin resistance with diet-induced obesity may therefore contribute to …

Background and aims A diminution in skeletal muscle mitochondrial function due to ectopic
lipid accumulation and excess nutrient intake is thought to contribute to insulin resistance …