The quality of mitochondria in skeletal muscle is essential for maintaining metabolic
homeostasis during adaptive stress responses. However, the precise control mechanism of …

Insulin resistance and blunted mitochondrial capacity in skeletal muscle are often
synonymous, however, this association remains controversial. The aim of this study was to …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Background In addition to its contractile properties and role in movement, skeletal muscle
plays an important function in regulating whole-body glucose and lipid metabolism. A central …

An accelerated rate of fat recovery (catch-up fat) and insulin resistance are characteristic
features of weight recovery after caloric restriction, with implications for the pathophysiology …

White adipose tissue (WAT) mitochondrial dysfunction is linked to the pathogenesis of
obesity driven insulin resistance. Dietary conditions that alter fat mass are known to affect …

The role of mitochondrial dysfunction in the development of insulin resistance and type 2
diabetes remains controversial. In order to specifically define the relationship between …

Objectives We assessed the alterations in mitochondrial function in skeletal muscle that
were elicited by short-term high-fat feeding in sedentary rats. Methods Two groups of rats …

Purpose Mitochondrial dysfunction and endoplasmic reticulum stress (ERS) are associated
with metabolic diseases such as obesity and Type 2 diabetes mellitus (T2DM). Mitochondria …

Mitochondrial dysfunction in white adipose tissue plays a key role in the pathogenesis of
type 2 diabetes. Emerging evidence specifically suggests that altered oxidative …