Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency

R Rossetti, I Ferrari, I Bestetti, S Moleri… - Human …, 2020 - Wiley Online Library
Abstract Bone morphogenetic protein 15 (BMP15) encodes an oocyte factor with a relevant
role for folliculogenesis as homodimer or cumulin heterodimer (BMP15‐GDF9) …

BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9

LC Patiño, KL Walton, TD Mueller… - The Journal of …, 2017 - academic.oup.com
Context: Bone morphogenetic protein (BMP) 15 is an oocyte-specific growth factor, which,
together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation …

BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein

R Rossetti, E Di Pasquale, A Marozzi, S Bione… - Human …, 2009 - Wiley Online Library
Abstract Bone morphogenetic protein‐15 (BMP15) is selectively synthesized by oocytes as a
pre‐proprotein and is considered an ovarian follicle organizer whose adequate function is …

Molecular biology and physiological role of the oocyte factor, BMP-15

RK Moore, S Shimasaki - Molecular and cellular endocrinology, 2005 - Elsevier
The oocyte factor, bone morphogenetic protein-15 (BMP-15) has proven to be critical for
normal fertility in female mammals. The biological functions of recombinant BMP-15 …

The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders

L Persani, R Rossetti, E Di Pasquale… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND A large number of studies have contributed to understanding the general
mechanisms driving ovarian folliculogenesis in humans and show a complex endocrine …

Identification of New Variants of Human BMP15 Gene in a Large Cohort of Women with Premature Ovarian Failure

E Di Pasquale, R Rossetti, A Marozzi… - The Journal of …, 2006 - academic.oup.com
Context: Premature ovarian failure (POF) is a cause of female infertility characterized by
primary (PA) or secondary amenorrhea (SA) and elevated gonadotropins. The pathogenesis …

Variants of the BMP15 gene in a cohort of patients with premature ovarian failure

D Tiotiu, B Alvaro Mercadal, R Imbert… - Human …, 2010 - academic.oup.com
BACKGROUND Bone morphogenetic protein 15 (BMP15) is an oocyte-derived growth factor
acting as a major player in follicle differentiation in mammals. Mutations in the BMP15 gene …

BMP15, fertility and the ovary

R Abir, B Fisch, MH Johnson - Reproductive BioMedicine Online, 2014 - rbmojournal.com
Premature ovarian failure (POF), also known as premature menopause, is defined as at
least six months of amenorrhea before the age of 40 with elevated gonadotrophins and …

Invited commentary: a single nucleotide polymorphism in BMP15 is associated with high response to controlled ovarian hyperstimulation

R Abir, B Fisch - Reproductive BioMedicine Online, 2011 - Elsevier
A report has been published which shows a connection between single nucleotide
polymorphisms (SNP) in the bone morphogenetic protein 15 (BMP15) gene and ovarian …

Oocyte bone morphogenetic protein 15, but not growth differentiation factor 9, is increased during gonadotropin-induced follicular development in the immature mouse …

X Guéripel, V Brun, A Gougeon - Biology of reproduction, 2006 - academic.oup.com
Bone morphogenetic protein (BMP) 15 and growth differentiation factor (GDF) 9 are oocyte-
secreted growth factors that are critical local regulators of ovarian function and may be …