Ischemic acute kidney injury is common, deadly, and accelerates the progression of chronic
kidney disease, yet has no specific therapy. After ischemia, reperfusion is patchy with early …

Acute renal failure (ARF) commonly occurs after whole body ischemia. Most experimental
models of ARF have relied on the isolated renal artery clamping model; however, there is a …

Several pathophysiological mechanisms have been purported to be involved in the
development of acute ischemic renal failure, such as impairment of tubular function and/or of …

Functional and structural abnormalities in the renal microvasculature are important
processes contributing to the pathophysiology of ischemic acute kidney injury (AKI). In this …

Acute renal failure commonly follows reduced renal perfusion or ischemia. Reperfusion is
essential for recovery but can itself cause functional and structural injury to the kidney. The …

Decreased renal blood flow following an ischemic insult contributes to a reduction in
glomerular filtration. However, little is known about the underlying cellular or subcellular …

It is not known whether a kidney with chronic structural and functional changes is more
vulnerable to an acute renal insult, and whether its regeneration capacity after injury is …

The renal microcirculation plays a major role in the delivery of blood and oxygen to the
kidney. In sepsis, alterations in renal microvascular perfusion, in conjunction with increased …

Ischaemia/reperfusion is a major cause of acute kidney injury in native and transplant
kidneys and is associated with significant morbidity and mortality. Murine models of renal …

Acute renal failure is a serious consequence of renal ischemia. The diagnosis carries an
associated high mortality rate. When blood flow to the kidneys is inadequate to supply …