One of the best-established findings in behavioural neuroscience is that mesocorticolimbic
dopamine (DA) transmission influences reward-related processes. Despite this consensus …

Drug addiction is marked by pathological drug seeking and intense drug craving, particularly
in response to drug-related stimuli. Repeated psychostimulant administration is known to …

Mesolimbic dopaminergic neurons are thought to serve as a final common neural pathway
for mediating reinforcement processes. However, several recent findings have challenged …

Background: Accumulating evidence indicates that drug-related cues can induce dopamine
(DA) release in the striatum of substance abusers. Whether these same cues provoke DA …

Although dopamine is implicated in the development of addiction, it is unclear how specific
dopamine release patterns are involved with drug seeking. Addictive drugs increase tonic …

Under the title “Dopamine 'ups and downs' in addiction revisited”, Samaha et al. discuss the
alteration of dopamine signaling evoked by repeated cocaine exposure, which may underlie …

Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

A challenging question that continues to plague the field of addiction is why some
individuals are more vulnerable for substance use disorders than others. Several important …

Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug
addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data …

Mesocorticolimbic dopamine transmission promotes reward pursuit. Based on these
observations, it has been proposed that individual differences in dopamine signaling might …