A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …

YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

Y box binding protein 1 (YB-1) oncoprotein at the hub of DNA proliferation, damage and cancer progression

F Sangermano, A Delicato, V Calabrò - Biochimie, 2020 - Elsevier
The Y Box binding protein 1 (YB-1) belongs to the highly conserved Cold Shock Domain
protein family and is a major component of messenger ribonucleoprotein particles (mRNPs) …

[HTML][HTML] Significance of the Y-box proteins in human cancers

K Matsumoto, BH Bay - Journal of molecular and genetic medicine …, 2005 - ncbi.nlm.nih.gov
Y-box proteins belong to the cold shock domain family of proteins that are known to be
involved in both transcriptional and translational control. Here, we give a brief overview of …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …

Novel insights into YB-1 signaling and cell death decisions

A Shah, JA Lindquist, L Rosendahl, I Schmitz… - Cancers, 2021 - mdpi.com
Simple Summary Signals that determine cell survival or death are essential for maintaining
tissue homeostasis. Cell death promotes the removal of unwanted cells; however, a failure …

Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycle

YN Yu, GWC Yip, PH Tan… - International …, 2010 - spandidos-publications.com
The Y-box-binding protein 1 (YB-1), a member of the cold-shock domain RNA-and DNA-
binding protein family, has pleiotropic functions such as regulation of the cell cycle. The aim …

Nuclear detection of Y-boxprotein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

E Dahl, A En-Nia, F Wiesmann, R Krings, S Djudjaj… - BMC cancer, 2009 - Springer
Background Y-box binding protein-1 (YB-1) is the prototypic member of the cold shock
protein family that fulfills numerous cellular functions. In the nucleus YB-1 protein …

YB‐1 protein: functions and regulation

DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

[HTML][HTML] YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression

J Wu, AL Stratford, A Astanehe… - Translational …, 2007 - ncbi.nlm.nih.gov
Abstract The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/
translation factor that is expressed in cancers affecting adults and children. It is now believed …