Evaluating the efficacy of oxytocin for pain management: an updated systematic review and meta-analysis

A Mekhael - 2022 - research.library.mun.ca
Currently available treatments for chronic pain rarely result in full recovery, indicating the
need for an analgesic that is non-addictive and effective. Oxytocin has recently gained …

Evaluating the efficacy of oxytocin for pain management: An updated systematic review and meta-analysis of randomized clinical trials and observational studies

AA Mekhael, JE Bent, JM Fawcett… - Canadian Journal of …, 2023 - Taylor & Francis
Background There is a need for novel analgesics with favorable risk to benefit profiles.
Oxytocin has recently gained attention for its potential analgesic properties. Aim The aim of …

Oxytocin and pain: a systematic review and synthesis of findings

JA Rash, A Aguirre-Camacho… - The Clinical journal of …, 2014 - journals.lww.com
Objectives: A review of the literature was conducted to assess the association between
oxytocin (OT) and pain. Methods: PsychInfo, PubMed, and Medline (EBSCO) research …

Oxytocin and the modulation of pain experience: Implications for chronic pain management

LM Tracy, N Georgiou-Karistianis, SJ Gibson… - Neuroscience & …, 2015 - Elsevier
In an acute environment pain has potential protective benefits. However when pain
becomes chronic this protective effect is lost and the pain becomes an encumbrance …

Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain

JC Eisenach, RS Curry, TT Houle - Pain Medicine, 2023 - academic.oup.com
Objective Compare intrathecal oxytocin, 100 µg to placebo on ongoing neuropathic pain
and mechanical hyperalgesia and allodynia. Study design Randomized, controlled, double …

The analgesic effects of oxytocin in the peripheral and central nervous system

Q Xin, B Bai, W Liu - Neurochemistry International, 2017 - Elsevier
Pain is a ubiquitously unpleasant feeling among humans as well as many animal species
often caused by actual and potential tissue damage. However, it is absolutely crucial for our …

Intrathecal oxytocin for neuropathic pain: A randomized, controlled, cross-over trial

JC Eisenach, RS Curry, TT Houle - medRxiv, 2022 - medrxiv.org
Objective To investigate the effect of intrathecal oxytocin compared to placebo on pain and
hypersensitivity in individuals with chronic neuropathic pain. Study design Randomized …

Effects of intranasal oxytocin on pain perception among human subjects: A systematic literature review and meta-analysis

S Lopes, F de Lima Osório - Hormones and Behavior, 2023 - Elsevier
Introduction Oxytocin (OXT) is a peptide hormone produced in the hypothalamus that plays a
neuromodulatory role in emotion, stress, and anxiety. Due to its multidimensional role, OXT …

Oxytocin: An expansive review of its mechanisms, functions, and therapeutic potential

Y Ueda - World Journal of Advanced Research and Reviews, 2023 - wjarr.com
Oxytocin, a neuropeptide crucial for social bonding and reproduction, has captivated
scientific interest due to its diverse mechanisms, physiological effects, and therapeutic …

[PDF][PDF] Joshua A. Rash, Tavis S. Campbell, 2 Lynn Cooper, 3 David Flusk, 4 Aaron MacInnes, 5 Maryam Nasr-Esfahani, 6, 7 Anastasia A. Mekhael

PA Poulin, M Robert, Y Yi11 - academia.edu
Introduction Current treatments for chronic pain (eg, opioids) can have adverse side effects
and rarely result in resolution of pain. As such, there is a need for adjuvant analgesics that …