Glycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to
that which is presented by healthy cells. One of such changes is appearing tumor …

The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …

Simple Summary MUC1 mucin with T antigen and galectin-3 with high affinity to T
disaccharide are both overexpressed in a variety of human cancers. Their mutual …

Mucins are major epithelial luminal surface proteins and function as a physical and
biological barrier protecting mucous epithelia. Diverse glycosylation of mucins potentially …

Intratumoral phenotypic diversity is well documented with regard to tumor associated
carbohydrate antigens (TACA). The factors which control the expression of these cell …

The type of interaction between tumor-associated antigens and specialized antigen-
presenting cells such as dendritic cells (DCs) is critical for the type of immunity that will be …

Protein glycosylation often changes during cancer development, resulting in the expression
of cancer-associated carbohydrate antigens. In particular mucins such as MUC1 are subject …

Altered glycosylation in epithelial cancers may play an important role in tumour progression,
as it may affect tumour cell migration and antigen presentation by antigen presenting cells …

MUC1 is a cell‐surface, epithelial glycoprotein that forms an essential protective barrier of
cells and serves to modulate intercellular communication. During cancer progression, the …

Simple Summary This work reviews the role of aberrant glycosylation in cancer cells during
tumour growth and spreading, as well as in immune evasion. The interaction of tumour …