Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to
A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites …

Gliotoxin is a nonribosomal peptide produced by Aspergillus fumigatus. This compound has
been proposed as an A. fumigatus virulence factor due to its cytotoxic, genotoxic, and …

Background. Gliotoxin is a epipolythiodioxopiperazine toxin that is made by the filamentous
fungus Aspergillus fumigatus. Gliotoxin has a wide range of effects on metazoan cells in …

Gliotoxin is a secondary metabolite produced by several fungi including the opportunistic
human pathogen Aspergillus fumigatus. As gliotoxin exerts immunosuppressive effects in …

Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence
factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production …

Gliotoxin is a member of the epipolythiodioxopiperazine class of toxins and is both the major
and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the …

Gliotoxin, and other related molecules, are encoded by multi-gene clusters and
biosynthesized by fungi using non-ribosomal biosynthetic mechanisms. Almost universally …

Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively
belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles …

Moulds produce several different mycotoxins that may improve their chance of survival in
particular environments. For example, Aspergillus fumigatus, an important human pathogen …

Aspergillus fumigatus causes a range of human and animal diseases collectively known as
aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of …