To elucidate the function of oxidative phosphorylation (OxPhos) during B cell differentiation,
we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the …

Almost 160 years after the discovery of mitochondria, they are known for their production of
energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been …

Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy,
and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an …

Lack of immune system cells or impairment in differentiation of immune cells is the basis for
many chronic diseases. Metabolic changes could be the root cause for this immune cell …

It is widely appreciated that T cells increase glycolytic flux during activation, but the role of
mitochondrial flux is unclear. Here, we have shown that mitochondrial metabolism in the …

Mitochondria are important signalling organelles, and they dictate immunological fate. From
T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that …

During immune reactions, functionally distinct B-cell subsets are generated by stochastic
processes, including class-switch recombination (CSR) and plasma cell differentiation …

Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell
activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by …

While once regarded as ATP factories, mitochondria have taken the spotlight as important
regulators of cellular homeostasis. The past two decades have witnessed an intensifying …

Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA
acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer …