Effective PEI-mediated delivery of CRISPR-Cas9 complex for targeted gene therapy
The-state-of-art CRISPR/Cas9 is one of the most powerful among the approaches being
developed to rescue fundamental causes of gene-based inheritable diseases. Several …
developed to rescue fundamental causes of gene-based inheritable diseases. Several …
Delivery of CRISPR/Cas9 by novel strategies for gene therapy
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …
[HTML][HTML] Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system
J O'Keeffe Ahern, I Lara-Sáez, D Zhou, R Murillas… - Gene therapy, 2022 - nature.com
Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an
efficient and safe delivery system into cells and tissues continues to hinder clinical …
efficient and safe delivery system into cells and tissues continues to hinder clinical …
[HTML][HTML] CRISPR/Cas9 delivery system engineering for genome editing in therapeutic applications
H Cheng, F Zhang, Y Ding - Pharmaceutics, 2021 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …
Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities
L Li, S Hu, X Chen - Biomaterials, 2018 - Elsevier
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …
(CRISPR-associated) genome editing systems have become one of the most robust …
[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …
[HTML][HTML] Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
S Zhang, J Shen, D Li, Y Cheng - Theranostics, 2021 - ncbi.nlm.nih.gov
CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …
however, the translation of this biotechnology into therapy has been hindered by efficient …
Progress of delivery methods for CRISPR-Cas9
Introduction Gene therapy is becoming increasingly common in clinical practice, giving hope
for the correction of a wide range of human diseases and defects. The CRISPR/Cas9 …
for the correction of a wide range of human diseases and defects. The CRISPR/Cas9 …
Carrier strategies boost the application of CRISPR/Cas system in gene therapy
Z Xu, Q Wang, H Zhong, Y Jiang, X Shi, B Yuan… - …, 2022 - Wiley Online Library
Emerging clustered regularly interspaced short palindromic repeat/associated protein
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …
[HTML][HTML] Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation
RA Foley, RA Sims, EC Duggan, JK Olmedo… - … in Bioengineering and …, 2022 - frontiersin.org
Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to selectively edit the human genome. Requiring …
(CRISPR/Cas9) has transformed our ability to selectively edit the human genome. Requiring …