Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications
A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …
Until the development of clustered regularly interspaced short palindromic repeats …
[HTML][HTML] CRISPR-Cas9 for in vivo gene therapy: Promise and hurdles
WJ Dai, LY Zhu, ZY Yan, Y Xu, QL Wang… - Molecular Therapy-Nucleic …, 2016 - cell.com
Owing to its easy-to-use and multiplexing nature, the genome editing tool CRISPR-Cas9
(clustered regularly interspaced short palindromic repeats (CRISPR) associated nuclease 9) …
(clustered regularly interspaced short palindromic repeats (CRISPR) associated nuclease 9) …
CRISPR/Cas9 ribonucleoprotein-mediated genome and epigenome editing in mammalian cells
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) system has revolutionized the ability to edit the mammalian genome, providing …
protein (Cas) system has revolutionized the ability to edit the mammalian genome, providing …
Ex vivo cell-based CRISPR/Cas9 genome editing for therapeutic applications
The recently developed CRISPR/Cas9 technology has revolutionized the genome
engineering field. Since 2016, increasing number of studies regarding CRISPR therapeutics …
engineering field. Since 2016, increasing number of studies regarding CRISPR therapeutics …
[HTML][HTML] A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing
AK Fajrial, QQ He, NI Wirusanti, JE Slansky, X Ding - Theranostics, 2020 - ncbi.nlm.nih.gov
Gene editing is a versatile technique in biomedicine that promotes fundamental research as
well as clinical therapy. The development of Clustered Regularly Interspaced Short …
well as clinical therapy. The development of Clustered Regularly Interspaced Short …
Direct cytosolic delivery of CRISPR/Cas9-ribonucleoprotein for efficient gene editing
Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP)
reduces unwanted gene targeting and avoids integrational mutagenesis that can occur …
reduces unwanted gene targeting and avoids integrational mutagenesis that can occur …
CRISPR/Cas9 genome editing for tissue‐specific in vivo targeting: nanomaterials and translational perspective
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated
endonuclease protein, ie, Cas9, have been discovered as an immune system in bacteria …
endonuclease protein, ie, Cas9, have been discovered as an immune system in bacteria …
A novel dual-targeting delivery system for specific delivery of CRISPR/Cas9 using hyaluronic acid, chitosan and AS1411
A facile method was designed that can specifically deliver CRISPR/Cas9 into target cells
nuclei and reduce the off-target effects. A multifunctional delivery vector for FOXM1 knockout …
nuclei and reduce the off-target effects. A multifunctional delivery vector for FOXM1 knockout …
CRISPR-cas9 genome editing delivery systems for targeted cancer therapy
The prokaryotic CRISPR–Cas systems could be applied as revolutionized genome editing
tool in live cells of various species to modify, visualize and identify definite sequences of …
tool in live cells of various species to modify, visualize and identify definite sequences of …
[HTML][HTML] Principles of CRISPR-Cas9 technology: advancements in genome editing and emerging trends in drug delivery
The rapid advancement of CRISPR-Cas9 technology has instigated a profound
transformation in genome editing with significant implications for fields like health …
transformation in genome editing with significant implications for fields like health …