CRISPR/Cas9-based application for cancer therapy: challenges and solutions for non-viral delivery
YQ Lin, KK Feng, JY Lu, JQ Le, WL Li, BC Zhang… - Journal of Controlled …, 2023 - Elsevier
CRISPR/Cas9 genome editing is a promising therapeutic technique, which makes precise
and rapid gene editing technology possible on account of its high sensitivity and efficiency …
and rapid gene editing technology possible on account of its high sensitivity and efficiency …
Challenges in CRISPR/CAS9 delivery: potential roles of nonviral vectors
CRISPR/Cas9 genome editing platforms are widely applied as powerful tools in basic
research and potential therapeutics for genome regulation. The appropriate alternative of …
research and potential therapeutics for genome regulation. The appropriate alternative of …
Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing
T Fang, X Cao, M Ibnat, G Chen - Journal of Nanobiotechnology, 2022 - Springer
The CRISPR-Cas9 technology has changed the landscape of genome editing and has
demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering …
demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering …
[HTML][HTML] Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine
M Khoshandam, H Soltaninejad, M Mousazadeh… - Genes & …, 2024 - Elsevier
CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …
Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid
A Jo, VM Ringel-Scaia, DK McDaniel… - Journal of …, 2020 - Springer
Background The clustered regularly interspaced short palindromic repeats (CRISPR) and
Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of …
Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of …
Multistage delivery nanoparticle facilitates efficient CRISPR/dCas9 activation and tumor growth suppression in vivo
CRISPR/dCas9 systems can precisely control endogenous gene expression without
interrupting host genomic sequence and have provided a novel and feasible strategy for the …
interrupting host genomic sequence and have provided a novel and feasible strategy for the …
Progress and challenges towards CRISPR/Cas clinical translation
D Rosenblum, A Gutkin, N Dammes, D Peer - Advanced Drug Delivery …, 2020 - Elsevier
CRISPR/Cas systems (clustered regularly interspaced short palindromic repeats) have
emerged as powerful tools to manipulate the genome for both research and therapeutic …
emerged as powerful tools to manipulate the genome for both research and therapeutic …
Delivery systems of CRISPR/Cas9-based cancer gene therapy
Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) is
today one of the most reliable method for gene-editing, supporting previous gene therapies …
today one of the most reliable method for gene-editing, supporting previous gene therapies …
Enhancement of target specificity of CRISPR–Cas12a by using a chimeric DNA–RNA guide
H Kim, W Lee, Y Oh, SH Kang, JK Hur… - Nucleic acids …, 2020 - academic.oup.com
The CRISPR–Cas9 system is widely used for target-specific genome engineering. CRISPR–
Cas12a (Cpf1) is one of the CRISPR effectors that controls target genes by recognizing …
Cas12a (Cpf1) is one of the CRISPR effectors that controls target genes by recognizing …
A single H1 promoter can drive both guide RNA and endonuclease expression in the CRISPR-Cas9 system
Z Gao, E Herrera-Carrillo, B Berkhout - Molecular Therapy-Nucleic Acids, 2019 - cell.com
The RNA-guided endonuclease Cas9 (CRISPR-Cas9) genome editing system has been
widely used for biomedical research and holds great potential for therapeutic applications in …
widely used for biomedical research and holds great potential for therapeutic applications in …