[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases
G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …
research era. Genome modification studies have traveled a long way from gene …
Nanoparticles-mediated CRISPR/Cas9 delivery: recent advances in cancer treatment
Clustered regularly interspaced short palindromic repeat-CRISPR-associated protein
(CRISPR-Cas) genome-editing systems, prokaryotic adaptive immune system, have been …
(CRISPR-Cas) genome-editing systems, prokaryotic adaptive immune system, have been …
Biomaterials as vectors for the delivery of CRISPR–Cas9
The emergence of the CRISPR–Cas9 gene editing system has brought much hope and
excitement to the field of gene therapy and the larger scientific community. However, in order …
excitement to the field of gene therapy and the larger scientific community. However, in order …
[HTML][HTML] Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system
T Sakuma, A Nishikawa, S Kume, K Chayama… - Scientific reports, 2014 - nature.com
CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic
modifications, not only for single gene targeting, but also for multiple targeted mutagenesis …
modifications, not only for single gene targeting, but also for multiple targeted mutagenesis …
Nucleic acid nanostructure for delivery of CRISPR/Cas9‐based gene editing system
W Tang, J Liu, B Ding - Interdisciplinary Medicine, 2023 - Wiley Online Library
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR‐
associated protein 9)‐based gene editing system has aroused great interest in many …
associated protein 9)‐based gene editing system has aroused great interest in many …
Delivery aspects of CRISPR/Cas for in vivo genome editing
D Wilbie, J Walther, E Mastrobattista - Accounts of chemical …, 2019 - ACS Publications
Conspectus The discovery of CRISPR/Cas has revolutionized the field of genome editing.
CRIPSR/Cas components are part of the bacterial immune system and are able to induce …
CRIPSR/Cas components are part of the bacterial immune system and are able to induce …
Endosomal escape and delivery of CRISPR/Cas9 genome editing machinery enabled by nanoscale zeolitic imidazolate framework
CRISPR/Cas9 is a combined protein (Cas9) and an engineered single guide RNA (sgRNA)
genome editing platform that offers revolutionary solutions to genetic diseases. It has …
genome editing platform that offers revolutionary solutions to genetic diseases. It has …
Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy
We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling,
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …
[HTML][HTML] The potential of CRISPR/Cas9 gene editing as a treatment strategy for inherited diseases
SA Abdelnour, L Xie, AA Hassanin, E Zuo… - Frontiers in cell and …, 2021 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR) is a promising
innovative technology for genomic editing that offers scientists the chance to edit DNA …
innovative technology for genomic editing that offers scientists the chance to edit DNA …
A dual-targeting delivery system for effective genome editing and in situ detecting related protein expression in edited cells
BY Liu, XY He, C Xu, L Xu, SL Ai, SX Cheng… - …, 2018 - ACS Publications
One of critical steps in genome editing by CRISPR-Cas9 is to deliver the CRISPR-Cas9
system into targeted cells. In this study, we developed a dual-targeting delivery system …
system into targeted cells. In this study, we developed a dual-targeting delivery system …