[HTML][HTML] Spexin and galanin in metabolic functions and social behaviors with a focus on non-mammalian vertebrates
Spexin (SPX) and galanin (GAL) are two neuropeptides that are phylogenetically related
and have descended from a common ancestral gene. Considerable attention has been …
and have descended from a common ancestral gene. Considerable attention has been …
Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus
A Pałasz, A Suszka-Świtek, A Kaśkosz… - Journal of Chemical …, 2021 - Elsevier
Neuropeptides are involved in numerous brain activities being responsible for a wide
spectrum of higher mental functions. The purpose of this concise, structural and qualitative …
spectrum of higher mental functions. The purpose of this concise, structural and qualitative …
Spexin: Its role, regulation, and therapeutic potential in the hypothalamus
Spexin is the most recently discovered member of the galanin/kisspeptin/spexin family of
peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic …
peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic …
Structure and functions of spexin as a new neuroendocrine signal
Ö Darakcı, A Bozkurt - Journal of Experimental and Clinical …, 2022 - dergipark.org.tr
Spexin (SPX) sa recently discovered endogenous peptide consisting of 14 amino acids. It
was found that SPX, kisspeptin (KISS), and galanin (GAL) peptides belong to the same gene …
was found that SPX, kisspeptin (KISS), and galanin (GAL) peptides belong to the same gene …
Spexin as a neuroendocrine signal with emerging functions
A Ma, J Bai, M He, AOL Wong - General and comparative endocrinology, 2018 - Elsevier
Spexin (SPX), a novel peptide coevolved with the galanin/kisspeptin family, was first
identified by bioinformatics prior to its protein purification/functional studies. Its mature …
identified by bioinformatics prior to its protein purification/functional studies. Its mature …
Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4
L Wang, A Tran, J Lee, DD Belsham - Molecular and Cellular …, 2020 - Elsevier
The function of the gonadotropin-releasing hormone (GnRH) neuron is critical to maintain
reproductive function and a significant decrease in GnRH can lead to disorders affecting …
reproductive function and a significant decrease in GnRH can lead to disorders affecting …
Mouse spexin:(II) functional role as a satiety factor inhibiting food intake by regulatory actions within the hypothalamus
Spexin (SPX) is a pleiotropic peptide with highly conserved protein sequence from fish to
mammals and its biological actions are mediated by GalR2/GalR3 receptors expressed in …
mammals and its biological actions are mediated by GalR2/GalR3 receptors expressed in …
[HTML][HTML] Evolution of structural and functional diversity of spexin in mammalian and non-mammalian vertebrate species
Spexin (SPX) is a novel neuropeptide, which was first identified in the human genome using
bioinformatics. Since then, orthologs of human SPX have been identified in mammalian and …
bioinformatics. Since then, orthologs of human SPX have been identified in mammalian and …
Molecular cloning, characterization and expression analysis of spexin in spotted scat (Scatophagus argus)
S Deng, H Chen, Y Zhai, L Jia, J Liu, M Wang… - General and …, 2018 - Elsevier
Spexin (Spx), a novel neuropeptide, composed of 14 amino acid residues, is evolutionally
conserved from fish to mammals. It has been suggested that Spx has pleiotropic functions in …
conserved from fish to mammals. It has been suggested that Spx has pleiotropic functions in …
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of
this peptide is currently under investigation. Here, we identified SPX along with a second …
this peptide is currently under investigation. Here, we identified SPX along with a second …