[HTML][HTML] Spexin and galanin in metabolic functions and social behaviors with a focus on non-mammalian vertebrates

I Mohd Zahir, S Ogawa, NA Dominic, T Soga… - Frontiers in …, 2022 - frontiersin.org
Spexin (SPX) and galanin (GAL) are two neuropeptides that are phylogenetically related
and have descended from a common ancestral gene. Considerable attention has been …

Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus

A Pałasz, A Suszka-Świtek, A Kaśkosz… - Journal of Chemical …, 2021 - Elsevier
Neuropeptides are involved in numerous brain activities being responsible for a wide
spectrum of higher mental functions. The purpose of this concise, structural and qualitative …

Spexin: Its role, regulation, and therapeutic potential in the hypothalamus

A Tran, W He, JTC Chen, DD Belsham - Pharmacology & therapeutics, 2022 - Elsevier
Spexin is the most recently discovered member of the galanin/kisspeptin/spexin family of
peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic …

Structure and functions of spexin as a new neuroendocrine signal

Ö Darakcı, A Bozkurt - Journal of Experimental and Clinical …, 2022 - dergipark.org.tr
Spexin (SPX) sa recently discovered endogenous peptide consisting of 14 amino acids. It
was found that SPX, kisspeptin (KISS), and galanin (GAL) peptides belong to the same gene …

Spexin as a neuroendocrine signal with emerging functions

A Ma, J Bai, M He, AOL Wong - General and comparative endocrinology, 2018 - Elsevier
Spexin (SPX), a novel peptide coevolved with the galanin/kisspeptin family, was first
identified by bioinformatics prior to its protein purification/functional studies. Its mature …

Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4

L Wang, A Tran, J Lee, DD Belsham - Molecular and Cellular …, 2020 - Elsevier
The function of the gonadotropin-releasing hormone (GnRH) neuron is critical to maintain
reproductive function and a significant decrease in GnRH can lead to disorders affecting …

Mouse spexin:(II) functional role as a satiety factor inhibiting food intake by regulatory actions within the hypothalamus

MKH Wong, Y Chen, M He, C Lin, Z Bian… - Frontiers in …, 2021 - frontiersin.org
Spexin (SPX) is a pleiotropic peptide with highly conserved protein sequence from fish to
mammals and its biological actions are mediated by GalR2/GalR3 receptors expressed in …

[HTML][HTML] Evolution of structural and functional diversity of spexin in mammalian and non-mammalian vertebrate species

CH Lim, MYM Lee, T Soga, I Parhar - Frontiers in endocrinology, 2019 - frontiersin.org
Spexin (SPX) is a novel neuropeptide, which was first identified in the human genome using
bioinformatics. Since then, orthologs of human SPX have been identified in mammalian and …

Molecular cloning, characterization and expression analysis of spexin in spotted scat (Scatophagus argus)

S Deng, H Chen, Y Zhai, L Jia, J Liu, M Wang… - General and …, 2018 - Elsevier
Spexin (Spx), a novel neuropeptide, composed of 14 amino acid residues, is evolutionally
conserved from fish to mammals. It has been suggested that Spx has pleiotropic functions in …

Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III

DK Kim, S Yun, GH Son, JI Hwang, CR Park… - …, 2014 - academic.oup.com
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of
this peptide is currently under investigation. Here, we identified SPX along with a second …