Recent studies on pathogenic streptococci have revealed that zinc is a pivotal metal ion in
their interaction with the host. In these streptococci, systems exist that ensure optimal use of …

Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions
including proper innate immune function. The host immune system has complicated and …

ABSTRACT “Cluster 9” family lipoproteins function as ligand-binding subunits of ABC-type
transporters in maintaining transition metal homeostasis and have been implicated in the …

Zinc plays an important role in host innate immune function. However, the innate immune
system also utilizes zinc starvation (“nutritional immunity”) to combat infections. Here, we …

Streptococcus pneumoniae is a globally significant pathogen that causes a range of
diseases, including pneumonia, sepsis, meningitis, and otitis media. Its ability to cause …

Background. Zinc plays an important role in human immunity, and it is known that zinc
deficiency in the host is linked to increased susceptibility to bacterial infection. In this study …

Due to its favorable chemical properties, zinc is used as a structural or catalytic cofactor in a
very large number of proteins. Despite the apparent abundance of this metal in all cell types …

An effective regulation of metal ion homeostasis is essential for the growth of
microorganisms in any environment and in pathogenic bacteria is strongly associated with …

Abstract Group A Streptococccus (GAS) is a major human pathogen that causes significant
morbidity and mortality. Zinc is an essential trace element required for GAS growth, however …

For bacterial pathogens whose sole environmental reservoir is the human host, the
acquisition of essential nutrients, particularly transition metals, is a critical aspect of survival …