Small molecules that bind to RNA potently and specifically are relatively rare. The study of
molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV …

The pharmacological disruption of the interaction between the HIV Tat protein and its
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …

Potent and selective recognition and modulation of disease-relevant RNAs remain a
daunting challenge. We previously examined the utility of the U1A N-terminal RNA …

The HIV-1 transactivation response (TAR) element–Tat interaction is a potentially valuable
target for treating HIV infection, but efforts to develop TAR-binding antiviral drugs have not …

The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …

RNA±protein interactions are essential for many biological processes such as translation,
RNA splicing, and transcription. For a long time, RNA was regarded mainly as a passive …

There has been little prior effort to discover new drugs on the basis of a unique RNA
structure. Binding of the viral transactivator Tat to the 5′ bulge of the transactivation …

The targeting of RNA for the design of novel anti-viral compounds represents an area of vast
potential. We have used NMR and computational methods to model the interaction of a …

An approach is described to the design of β-hairpin peptidomimetic ligands for bovine
immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response …

Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …