No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …

Gene therapy includes the application of various viral vectors, which represent most types
and families of viruses, suitable for infection of mammalian host cells. Both hereditary …

The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

The use of viruses to transduce genes of interest into mammalian cells has been extremely
revolutionary, both in terms of laboratory research and for clinical purposes. This approach …

Although most research in the field of somatic gene therapy has investigated the use of
recombinant viruses for transferring genes into somatic target cells, various methods for …

Problems related to the safety and efficacy of gene therapies have checked the enthusiasm
once surrounding this field, though it remains a promising approach for the treatment of …

Viral vector is the most effective means of gene transfer to modify specific cell type or tissue
and can be manipulated to express therapeutic genes. Several virus types are currently …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …

In recent years, the development of powerful viral gene transfer techniques has greatly
facilitated the study of gene function. This review summarises some of the viral delivery …