With the development of the first viral vector systems 20 years ago [Mann et al., 1983;
Watanabe and Temin, 1983] gene therapy strategies have come to the forefront of novel …

Gene therapies are currently one of the most investigated therapeutic modalities in both the
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …

Retroviral vectors have become a standard tool for gene transfer technology. Compared with
other gene transfer systems, retroviral vectors have several advantages, including their …

Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or
at least to improve the clinical status of a patient. One of the basic concepts of gene therapy …

Various methods have been developed to transfer and express genes in mammalian cells.
Each method, whether virally, non-virally, or physically-based, has unique favorable …

Gene therapy is an interesting approach for the correction of defective genes, the treatment
of cancer and the introduction of immunomodulatory genes. Various techniques for gene …

The main objective in gene therapy is the development of efficient, non-toxic gene carriers
that can encapsulate and deliver foreign genetic materials into specific cell types such as …

Although the genetic therapy of human diseases has been conceptually possible for many
years we still lack a vector system that allows safe and reproducible genetic modification of …

Cancer is a multigenic disorder involving mutations of both tumor suppressor genes and
oncogenes. A large body of preclinical data, however, has suggested that cancer growth can …

The goal of tissue engineering is the production of functional, biocompatible tissues by
seeding cells within biological or synthetic scaffolds. One tissue engineering approach …