Naphthoquinone derivatives isolated from plants: recent advances in biological activity

ES Ahmadi, A Tajbakhsh, M Iranshahy… - Mini Reviews in …, 2020 - ingentaconnect.com
Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are
the subject of increasing attention due to their promising biological activities such as …

Understanding cancer and the anticancer activities of naphthoquinones–a review

KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …

The relevance and insights on 1, 4-naphthoquinones as antimicrobial and antitumoral molecules: A systematic review

G Navarro-Tovar, S Vega-Rodríguez, E Leyva… - Pharmaceuticals, 2023 - mdpi.com
Natural product derivatives are essential in searching for compounds with important
chemical, biological, and medical applications. Naphthoquinones are secondary …

Recent development on naphthoquinone derivatives and their therapeutic applications as anticancer agents

VK Tandon, S Kumar - Expert Opinion on Therapeutic Patents, 2013 - Taylor & Francis
Introduction: A large number of natural products including several synthetic drugs possess
naphthoquinone chromophore. Various methods have been devised for their synthesis …

Noteworthy secondary metabolites naphthoquinones-their occurrence, pharmacological properties and analysis

P Babula, V Adam, L Havel… - Current Pharmaceutical …, 2009 - ingentaconnect.com
Chemical investigation of many bacterial and fungal, as well as plant species has revealed
the presence of interesting compounds derived from naphthalene-1, 4-naphthoquinones …

[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties

E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents

HY Qiu, PF Wang, HY Lin, CY Tang… - Chemical biology & …, 2018 - Wiley Online Library
Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been
implicated with human life since ancient time, far earlier than their isolation and identification …

Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis

CL Gomes, VAW Sales, CG de Melo, RMF da Silva… - Phytochemistry, 2021 - Elsevier
Abstract β-Lapachone is an ortho-naphthoquinone originally isolated from the heartwood of
Handroanthus impetiginosus and can be obtained through synthesis from lapachol …

Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol

EL Bonifazi, C Ríos-Luci, LG León, G Burton… - Bioorganic & medicinal …, 2010 - Elsevier
A series of 5-hydroxy-1, 4-naphthoquinones analogues was synthesized from juglone (6)
and their antiproliferative activity against a representative panel of six human solid tumor cell …

Naphthoquinones and derivatives as potential anticancer agents: An updated review

MM Rahman, MR Islam, S Akash, S Shohag… - Chemico-Biological …, 2022 - Elsevier
One of the leading global causes of death is cancer; even though several treatment methods
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …