Exposure to adversity and stress early in development yields vulnerability to mental
illnesses throughout the lifespan. Growing evidence suggests that this vulnerability has …

Adversity in early childhood exerts an enduring impact on mental and physical health,
academic achievement, lifetime productivity, and the probability of interfacing with the …

The overarching objective is to review how early exposure to adversity interacts with
inflammation to alter brain maturation. Both adversity and inflammation are significant risk …

Early exposure to psychosocial adversity is among the most potent predictors of depression.
Because depression commonly emerges prior to adulthood, we must consider the …

Maltreatment and trauma in childhood, termed early-life stress (ELS), has long-term effects
on the immune system. ELS impacts immune signaling at the time of exposure but also …

Children who experience chronic stressors are vulnerable to emotional and physical health
problems across the lifespan. This phenomenon raises questions for scientists and …

Childhood adversity is associated with a host of mental and physical health problems across
the lifespan. Individuals who have experienced childhood adversity (eg, child abuse and …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

Early adverse experiences are associated with heighted vulnerability for stress-related
psychopathology across the lifespan. While extensive work has investigated the effects of …

The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …