Valvular heart disease has a major impact on patient morbidity and mortality on a global
scale. Current heart valve replacement options present with numerous limitations. These …

Decellularized heart valves have great potential as a stand-alone valve replacement or as a
scaffold for tissue engineering heart valves. Before decellularized valves can be widely used …

More than 1000 donated aortic and pulmonary valves from predominantly European tissue
banks were centrally decellularized and delivered to hospitals in Europe and Japan. Here …

Non-fixed, decellularized allogeneic heart valve scaffolds seem to be the best choice for
heart valve replacement, their availability, however, is quite limited. Cryopreservation could …

Background Glutaraldehyde fixed xenogeneic heart valve prosthesis are hindered by
calcification and lack of growth potential. The aim of tissue decellularization is to remove …

Decellularised pulmonary valve roots are a promising regenerative solution for
reconstruction of the right ventricular outflow tract in young patients. Application of a robust …

Aortic valvular disease is a severe ailment that causes great suffering and many deaths
worldwide. The exponentially increasing prevalence of the disease has accelerated the …

Background Cardiac valve replacement is the only available treatment for end-stage
valvular dysfunction patients. In this treatment, among the available choices of valves, the …

When a tissue or an organ is considered, the attention inevitably falls on the complex and
delicate mechanisms regulating the correct interaction of billions of cells that populate it …

Abstract Annually, over 50,000 deaths are attributed to heart valve disease (HVD) in the
United States. The most common treatment for HVD, such as stenosis and regurgitation, is …