Melatonin is an important endogenous hormone that shows antioxidant functions and
pleiotropic effects, playing a crucial role in animal reproduction. Ovary granulosa cells (GCs) …

Oxidative stress has been implicated in various aspects of aging, but the role of oxidative
stress in ovarian aging remains unclear. Our previous studies have shown that the initiation …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

Aims Previous reports have demonstrated that melatonin exists in multiple extrapineal sites,
and higher amounts of melatonin are present in human follicular fluid than in serum, which …

Hydroxycamptothecin (HCPT) is a widely used anticancer drug that induces cytotoxicity by
triggering the cell apoptotic pathway. Studies have shown that HCPT has harmful effects on …

We investigated the relationship between oxidative stress and poor oocyte quality and
whether the antioxidant melatonin improves oocyte quality. Follicular fluid was sampled at …

The physiology of oocyte in vitro maturation remains elusive. Generally, the oocytes have a
very low maturation rate under in vitro conditions. In the current study, we found that …

Abstract Di (2-ethylhexyl) phthalate (DEHP), an estrogen-like compound that is a ubiquitous
environmental contaminant, has been reported to adversely affect human and mammalian …

Melatonin is a hormone mainly secreted by the pineal gland during the circadian cycle, with
low levels during the daytime and prominent levels during the night. It is involved in …

Although the role of oxidative stress in maternal aging and infertility has been suggested, the
underlying mechanisms are not fully understood. The present study is designed to …