Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Rationale Asthma has substantial morbidity and mortality and a strong genetic component,
but identification of genetic risk factors is limited by availability of suitable studies. Objectives …

Background Genome-wide association studies (GWAS) have discovered genetic variants
that predispose individuals to asthma. To integrate these new discoveries with emerging …

Genome-wide association studies (GWAS) of asthma have yielded exciting results and
identified novel risk alleles and loci. But, like other common complex diseases, asthma …

Background Childhood-onset and adult-onset asthma differ with respect to severity and
comorbidities. Whether they also differ with respect to genetic risk factors has not been …

Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …

Asthma is a complex disease with sex-specific differences in prevalence. Candidate gene
studies have suggested that genotype-by-sex interaction effects on asthma risk exist, but this …

The extent to which genetic risk factors are shared between childhood-onset (COA) and
adult-onset (AOA) asthma has not been estimated. On the basis of data from the UK Biobank …

The first genome wide association study (GWAS) for childhood asthma identified a novel
major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role …

Background The genetic basis for developing asthma has been extensively studied.
However, association studies to date have mostly focused on mild to moderate disease and …