[HTML][HTML] Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
Asthma is a chronic and genetically complex respiratory disease that affects over 300 million
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Children's Health Study (CHS) and HARBORS study … - Nature …, 2011 - nature.com
Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …
environmental factors. We performed a meta-analysis of North American genome-wide …
Genetic polymorphisms and associated susceptibility to asthma
ME March, PMA Sleiman… - International journal of …, 2013 - Taylor & Francis
As complex common diseases, asthma and allergic diseases are caused by the interaction
of multiple genetic variants with a variety of environmental factors. Candidate-gene studies …
of multiple genetic variants with a variety of environmental factors. Candidate-gene studies …
[HTML][HTML] Advances in asthma and allergic disease genetics: Is bigger always better?
N Schoettler, E Rodríguez, S Weidinger… - Journal of Allergy and …, 2019 - Elsevier
This review focuses on genome-wide association studies (GWASs) of asthma and allergic
diseases published between January 1, 2018, and June 30, 2019. During this time period …
diseases published between January 1, 2018, and June 30, 2019. During this time period …
Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis
Asthma is a heterogeneous respiratory disease reflecting distinct pathobiologic
mechanisms. These mechanisms are based, at least partly, on different genetic factors …
mechanisms. These mechanisms are based, at least partly, on different genetic factors …
[HTML][HTML] Lessons learned from GWAS of asthma
Asthma is a common complex disease of the airways. Genome-wide association studies
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …
Genetic heterogeneity of asthma phenotypes identified by a clustering approach
V Siroux, JR González, E Bouzigon… - European …, 2014 - Eur Respiratory Soc
The aim of the study was to identify genetic variants associated with refined asthma
phenotypes enabling multiple features of the disease to be taken into account. Latent class …
phenotypes enabling multiple features of the disease to be taken into account. Latent class …
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
Clinical and epidemiological data suggest that asthma and allergic diseases are associated
and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma …
and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma …
Genome‐wide association studies for discovery of genes involved in asthma
L Akhabir, AJ Sandford - Respirology, 2011 - Wiley Online Library
Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …
variants that confer susceptibility. Studies of the genetics of asthma have previously been …
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
Rationale: Association studies have implicated many genes in asthma pathogenesis, with
replicated associations between single-nucleotide polymorphisms (SNPs) and asthma …
replicated associations between single-nucleotide polymorphisms (SNPs) and asthma …