Fluorochemicals for medical use are metabolically inert liquids with a high solubility for
gases, and can dissolve 50 percent or more of their own volume of oxygen (O2) at ambient …

Two major areas of research of the oxygen carrying solutions are 1) utilization of
hemoglobin and 2) perfluorochemicals. Even though they are not perfect red blood cell …

Forthcoming shortfall of blood products and persisting concerns about viral transmission and
immunosuppressive side effects of allogeneic blood transfusion have reinforced the studies …

The development of perfluorocarbon (PFC) solutions as clinically useful oxygen-carrying
agents has been a slow process because PFC is immiscible in aqueous solutions, including …

The in vivo study of microvascular oxygen transport requires accurate and challenging
measurements of several mass transfer parameters. Although recommended, blood flow …

Objectives We discuss two main categories of blood substitutes: perfluorocarbons and
hemoglobin-based oxygen carriers. Methods We provide a review of the notable products …

A high-concentration 90% w/v perflubron (perfluorooctyl bromide [PFOB]) emulsion
(Oxygent™ HT) is being evaluated as an oxygen carrier for use during surgery. This study …

Inherent risks and increasing costs of allogeneic transfusions underline the socioeconomic
relevance of safe and effective alternatives to banked blood. The safety limits of a restrictive …

Context.—There is no true substitute for the many functions of human red blood cells, and
synthetic products will not replace the need for blood donation in the foreseeable future …