Search for multiple myeloma risk factors using Mendelian randomization

M Went, AJ Cornish, PJ Law, B Kinnersley… - Blood …, 2020 - ashpublications.org
The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-
wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian …

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

JS Mitchell, N Li, N Weinhold, A Försti, M Ali… - Nature …, 2016 - nature.com
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis.
Genome-wide association studies have transformed our understanding of MM …

Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma

JS Mitchell, DC Johnson, K Litchfield, P Broderick… - Scientific reports, 2015 - nature.com
A sizeable fraction of multiple myeloma (MM) is expected to be explained by heritable
factors. Genome-wide association studies (GWAS) have successfully identified a number of …

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

M Went, B Kinnersley, A Sud, DC Johnson… - Human genomics, 2019 - Springer
Background While genome-wide association studies (GWAS) of multiple myeloma (MM)
have identified variants at 23 regions influencing risk, the genes underlying these …

Direct evidence for a polygenic etiology in familial multiple myeloma

BM Halvarsson, AK Wihlborg, M Ali… - Blood …, 2017 - ashpublications.org
Although common risk alleles for multiple myeloma (MM) were recently identified, their
contribution to familial MM is unknown. Analyzing 38 familial cases identified primarily by …

Genetic predisposition for multiple myeloma

M Pertesi, M Went, M Hansson, K Hemminki… - Leukemia, 2020 - nature.com
Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological
family studies going back to the 1920s have provided evidence for familial aggregation …

Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance

AI Clay-Gilmour, MAT Hildebrandt, EE Brown… - Blood …, 2020 - ashpublications.org
So far, 23 germline susceptibility loci have been associated with multiple myeloma (MM)
risk. It is unclear whether the genetic variation associated with MM susceptibility also …

Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations—an extensive replication of the associations from the candidate …

A Martino, D Campa, A Jurczyszyn… - … , biomarkers & prevention, 2014 - AACR
Background: Genetic background plays a role in multiple myeloma susceptibility. Several
single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple …

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

M Went, A Sud, A Försti, BM Halvarsson… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) have transformed our understanding of
susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained …

Identification of novel genetic loci for risk of multiple myeloma by functional annotation

A Macauda, K Briem, A Clay-Gilmour, W Cozen… - Leukemia, 2023 - nature.com
Multiple myeloma (MM) is one of the most common hematological malignancies, accounting
for 20% of all newly diagnosed hematological cancers [1]. The most recent data from Cancer …