In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in
levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that …

The mammalian cell contains a molecular clock that contributes, within each organism, to
circadian rhythms and variety of physiological and metabolic processes. The clock …

Many metabolic and physiological processes display circadian oscillations. We have shown
that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is …

Introduction The circadian clock is a transcriptional oscillator that is thought to couple
internal energetic processes with the solar cycle. Circadian oscillation in activity of …

Calorie restriction abates aging and cardiometabolic disease by activating metabolic
signaling pathways, including nicotinamide adenine dinucleotide (NAD+) biosynthesis and …

Circadian rhythms govern a wide variety of physiological and metabolic functions in many
organisms, from prokaryotes to humans. We previously reported that silent information …

Sirtuin 3 (SIRT3), an important regulator of energy metabolism and lipid oxidation, is
induced in fasted liver mitochondria and implicated in metabolic syndrome. In fasted liver …

Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily
anticipation of the light/dark cycle and separation of energy storage and utilization cycles on …

Emerging evidence suggests that protein acetylation is a broad-ranging regulatory
mechanism. Here we utilize acetyl-peptide arrays and metabolomic analyses to identify …

SIRT1 is a highly-conserved NAD+-dependent protein deacetylase that plays essential roles
in the regulation of energy metabolism, genomic stability, and stress response. Although the …