Loss-of-function mutations in progranulin (GRN) are a major genetic cause of frontotemporal
dementia (FTD), possibly due to loss of progranulin's neurotrophic and anti-inflammatory …

Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …

Progranulin is a widely expressed protein that is involved in the regulation of multiple
biological processes, including embryogenesis, host defense, and wound repair. In the …

Frontotemporal lobar dementia (FTLD) is the most common cause of dementia in patients
younger than 60 years of age, and causes progressive neurodegeneration of the frontal and …

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …

Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in
a form of frontotemporal lobar degeneration that is characterized by the presence of …

It is well known that progranulin protein is involved in wound repair, inflammation, and tumor
formation. The wedding between progranulin and brain was celebrated in 2006 with the …

Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause
neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia …