Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism

S Cappello, T Angelone, B Tota… - American Journal …, 2007 - journals.physiology.org
The acidic protein chromogranin A (CgA) is the precursor of several regulatory peptides
generated by specific proteolytic processes. Human recombinant CgA NH2-terminal …

The homologous rat chromogranin A1‐64 (rCGA1‐64) modulates myocardial and coronary function in rat heart to counteract adrenergic stimulation indirectly via …

MC Cerra, MP Gallo, T Angelone… - The FASEB …, 2008 - Wiley Online Library
Chromogranin A (CGA), produced by human and rat myocardium, generates several
biologically active peptides processed at specific proteolytic cleavage sites. A highly …

Recombinant N–terminal fragments of chromogranin–a modulate cardiac function of the Langendorff–perfused rat heart

MC Cerra, L De Iuri, T Angelone, A Corti… - Basic research in …, 2006 - Springer
In this study we tested the hypothesis that vasostatins could act as myocardial modulators in
the mammalian heart. Using the Langendorff–perfused rat heart, the cardiac effects of the …

The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress

R Mazza, S Imbrogno, B Tota - Regulatory peptides, 2010 - Elsevier
Chromogranin A (CgA) is the major soluble protein co-stored and co-released with
catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells …

Cardioprotection Against Ischemia/Reperfusion Injury and Chromogranin ADerived Peptides

C Penna, F Tullio, MG Perrelli… - Current medicinal …, 2012 - ingentaconnect.com
Chromogranin A (CgA) is produced by cells of the sympathoadrenal system and by human
ventricular myocardium. In the clinical setting CgA has been mainly used as a marker of …

Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function

M Pieroni, A Corti, B Tota, F Curnis… - European heart …, 2007 - academic.oup.com
Abstract Aims High chromogranin-A (CgA) levels were observed in patients with heart failure
but its source remained uncertain. We evaluated whether CgA is produced by myocardium …

Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA1-64) in the rat heart

T Angelone, AM Quintieri, Y Goumon, V Di Felice… - Regulatory peptides, 2010 - Elsevier
Cytoskeleton scaffold in cardiac myocytes provides structural support and
compartmentalization of intracellular components. It is implicated in cardiac pathologies …

Endothelium dependent cardiovascular effects of the chromogranin A-derived peptides vasostatin-1 and catestatin

S Fornero, E Bassino, MP Gallo… - Current medicinal …, 2012 - ingentaconnect.com
The involvement of Chromogranin A (CgA) in the cardiovascular function regulation is
attributed to its function as a prohormone. Several studies indicated that CgA-derived …

Full-length human chromogranin-A cardioactivity: myocardial, coronary, and stimulus-induced processing evidence in normotensive and hypertensive male rat hearts

T Pasqua, A Corti, S Gentile, L Pochini, M Bianco… - …, 2013 - academic.oup.com
Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular
diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an …

The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions

KB Helle - Cardiovascular research, 2010 - academic.oup.com
A range of inflammatory conditions is associated with pathologically high levels of circulating
chromogranin A (CgA). This prohormone belongs to the family of uniquely acidic proteins co …