Endogenous Bufadienolide, Blood Pressure and Alcohol Withdrawal

VA Kashkin, AY Egorov, EM Krupitsky… - Current Hypertension …, 2021 - ingentaconnect.com
Background and Objective: Previously, it was demonstrated that marinobufagenin (MBG) is
implicated in the development of ethanol withdrawal in rats. It has been shown that ethanol …

Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats

VA Kashkin, EE Zvartau, OV Fedorova… - European …, 2008 - Elsevier
An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin
(MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG …

Marinobufagenin in urine: a potential marker of predisposition to ethanol and a target for spironolactone

VA Kashkin, EV Shekunova, AY Egorov… - Current Hypertension …, 2018 - ingentaconnect.com
Background and Objective: Previously it was demonstrated that digitalis-like cardiotonic
steroid, marinobufagenin (MBG), is implicated in the development of ethanol addiction in …

Revealing of endogenous Marinobufagin by an ultra-specific and sensitive UHPLC-MS/MS assay in pregnant women

C Lenaerts, L Bond, R Tuytten, B Blankert - Talanta, 2018 - Elsevier
Marinobufagenin (MBG) is a bufadienolide cardiac inotrope implicated in volume expansion-
mediated hypertensive states including essential hypertension and preeclampsia (PE) …

Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl …

OV Fedorova, AS Simbirtsev, NI Kolodkin… - Journal of …, 2008 - journals.lww.com
Background Levels of marinobufagenin (MBG), an endogenous bufadienolide Na/K-ATPase
(NKA) inhibitor, increase in preeclampsia and in NaCl-sensitive hypertension. Methods We …

Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage

RI Dmitrieva, AY Bagrov, E Lalli, P Sassone-Corsi… - …, 2000 - Am Heart Assoc
An increasing body of evidence suggests that an endogenous mammalian bufadienolide
(BD) may be involved in the regulation of Na+, K+-ATPase activity and the pathogenesis of …

Analytical aspects of marinobufagenin

C Lenaerts, M Demeyer, P Gerbaux, B Blankert - Clinica Chimica Acta, 2013 - Elsevier
Marinobufagenin (MBG), a steroid compound belonging to the bufadienolide cardiac
inotropes, is a molecule enjoying a growing interest in the early diagnostic of volume …

Butanediol conversion to gamma‐hydroxybutyrate markedly reduced by the alcohol dehydrogenase blocker fomepizole

E Liakoni, H Gugelmann, DA Dempsey… - Clinical …, 2019 - Wiley Online Library
1, 4‐Butanediol (BDO)—used as solvent and abused for its euphoric effects—is converted to
gamma‐hydroxybutyrate (GHB) by the enzyme alcohol dehydrogenase. This double‐blind …

[PDF][PDF] Marinobufagenin in hypertensive patients with obstructive sleep apnea

NE Zvartau, AO Conrady, YV Sviryaev… - Cell Mol Biol (Noisy …, 2006 - researchgate.net
Although obstructive sleep apnea (OSA) is an independent risk factor for hypertension, the
underlying mechanisms are not clearly understood. Apnea and hypopnea episodes during …

Emerging role of the bufadienolides in cardiovascular and kidney diseases

JB Puschett, E Agunanne, MN Uddin - American journal of kidney diseases, 2010 - Elsevier
The bufadienolides are a group of steroid hormones that circulate in blood and are excreted
in urine. They have the ability to inhibit the adenosine triphosphatase sodium-potassium …