Conditional deletion of Hspa5 leads to spermatogenesis failure and male infertility in mice

Z Wen, H Zhu, J Wang, B Wu, A Zhang, H Zhao… - Life Sciences, 2023 - Elsevier
Heat shock proteins (HSPs) have important roles in different developmental stages of
spermatogenesis. The heat shock 70 kDa protein 5 (HSPA5) is an important component of …

[HTML][HTML] The heat shock protein family gene Hspa1l in male mice is dispensable for fertility

X Wang, W Xie, Y Yao, Y Zhu, J Zhou, Y Cui, X Guo… - PeerJ, 2020 - peerj.com
Background Heat shock protein family A member 1 like (Hspa1l) is a member of the 70kD
heat shock protein (Hsp70) family. HSPA1L is an ancient, evolutionarily conserved gene …

Heat-shock protein HSPA4 is required for progression of spermatogenesis

T Held, AZ Barakat, BA Mohamed, I Paprotta… - …, 2011 - rep.bioscientifica.com
Abstract Heat-shock protein 110 (HSP110) family members act as nucleotide exchange
factors (NEF) of mammalian and yeast HSP70 chaperones during the ATP hydrolysis cycle …

Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development

T Held, I Paprotta, J Khulan… - … and Cellular Biology, 2006 - Am Soc Microbiol
The Hspa4l gene, also known as Apg1 or Osp94, belongs to the HSP110 heat shock gene
family, which includes three genes encoding highly conserved proteins. This study shows …

Heat shock protein A2 (HSPA2): Regulatory roles in germ cell development and sperm function

B Nixon, EG Bromfield, J Cui, GN De Iuliis - … Role of Heat Shock Proteins in …, 2017 - Springer
Among the numerous families of heat shock protein (HSP) that have been implicated in the
regulation of reproductive system development and function, those belonging to the 70 kDa …

Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse

EG Bromfield, RJ Aitken… - MHR: Basic science of …, 2017 - academic.oup.com
STUDY QUESTION Does oxidative stress compromise the protein expression of heat shock
protein A2 (HSPA2) in the developing germ cells of the mouse testis? SUMMARY ANSWER …

Decreased expression of heat shock protein A4L in spermatozoa is positively related to poor human sperm quality

XX Liu, X Wang, FJ Liu - Molecular Reproduction and …, 2019 - Wiley Online Library
Heat shock protein A4L (HSPA4L), which is highly expressed in the testis, is correlated with
male fertility. However, the relationship between HSPA4L expression and sperm quality …

The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition

B Nixon, EG Bromfield, MD Dun… - Asian Journal of …, 2015 - journals.lww.com
One of the most common lesions present in the spermatozoa of human infertility patients is
an idiopathic failure of sperm-egg recognition. Although this unique cellular interaction can …

Depression of HspA2 in human testis is associated with spermatogenic impairment and fertilization rate in ICSI treatment for azoospermic individuals

Y Tian, F Zhang, X Zhang, L Li, L Wang, B Shi… - Journal of assisted …, 2014 - Springer
Purpose Heat shock protein A2 (HspA2) expression was quantitatively measured in human
testis and its relationship with the spermatogenetic status and laboratory outcomes of …

MAPKAP kinase 2–mediated phosphorylation of HspA1L protects male germ cells from heat stress–induced apoptosis

PA Williams, HE Kobilnyk, EA McMillan… - Cell Stress and …, 2019 - Springer
Developing male germ cells are extremely sensitive to heat stress; consequently, anatomic
and physiologic adaptations have evolved to maintain proper thermoregulation during …