Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Background and objectives Vascular risk factors and elevated β-amyloid (Aβ) are commonly
observed together among older adults. Here, we examined the interactive vs independent …

Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship …

Background Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their
influence on neurodegeneration and cognition in predementia stages remains unclear. We …

Importance Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques
to initiate neurodegeneration within AD-affected regions. However, some cognitively normal …

Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

Background/Objective: To determine the impact of vascular burden on rates of decline in
episodic memory and executive function. We hypothesize that greater vascular burden will …

Background and Purpose: Cerebrovascular disease (CVD) pathologies including vessel
disease (atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy) and tissue …