[HTML][HTML] New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia
S Amin, G Carling, L Gan - Current Opinion in Neurobiology, 2022 - Elsevier
Frontotemporal dementia (FTD) is the second most common form of dementia. It affects the
frontal and temporal lobes of the brain and has a highly heterogeneous clinical …
frontal and temporal lobes of the brain and has a highly heterogeneous clinical …
Approaches to develop therapeutics to treat frontotemporal dementia
LP Elia, T Reisine, A Alijagic, S Finkbeiner - Neuropharmacology, 2020 - Elsevier
Frontotemporal degeneration (FTD) is a complex disease presenting as a spectrum of
clinical disorders with progressive degeneration of frontal and temporal brain cortices and …
clinical disorders with progressive degeneration of frontal and temporal brain cortices and …
Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
MC Chang, K Srinivasan, BA Friedman… - Journal of Experimental …, 2017 - rupress.org
Loss-of-function mutations in GRN cause frontotemporal dementia (FTD) with transactive
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …
Progranulin: an emerging target for FTLD therapies
J Gass, M Prudencio, C Stetler, L Petrucelli - Brain research, 2012 - Elsevier
Frontotemporal lobar degeneration (FTLD), a neurodegenerative disease primarily affecting
the frontal and temporal lobes, is one of the most common types of dementia. While the …
the frontal and temporal lobes, is one of the most common types of dementia. While the …
[HTML][HTML] Progranulin axis and recent developments in frontotemporal lobar degeneration
AM Nicholson, J Gass, L Petrucelli… - Alzheimer's Research & …, 2012 - Springer
Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that
is the second most common form of dementia affecting individuals under age 65. The most …
is the second most common form of dementia affecting individuals under age 65. The most …
[HTML][HTML] Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD
Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin
(PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is …
(PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is …
[HTML][HTML] Preclinical interventions in mouse models of frontotemporal dementia due to progranulin mutations
SN Kashyap, NR Boyle, ED Roberson - Neurotherapeutics, 2023 - Elsevier
Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …
Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
M Cruts, S Kumar-Singh… - Current Alzheimer …, 2006 - ingentaconnect.com
Two genetically distinct types of frontotemporal dementia (FTD) are linked to chromosome
17q21. FTD with parkinsonism (FTDP-17) results from mutations in the gene encoding …
17q21. FTD with parkinsonism (FTDP-17) results from mutations in the gene encoding …
Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
AS Chen-Plotkin, J Xiao, F Geser, M Martinez-Lage… - Acta …, 2010 - Springer
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is characterized by
progressive decline in behavior, executive function, and language. Progranulin (GRN) gene …
progressive decline in behavior, executive function, and language. Progranulin (GRN) gene …
Dissociation of frontotemporal dementia–related deficits and neuroinflammation in progranulin haploinsufficient mice
AJ Filiano, LH Martens, AH Young… - Journal of …, 2013 - Soc Neuroscience
Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …