Objectives ABCB1 gene polymorphisms can modify P-glycoprotein function with clinical
consequences. Methods The 3435C> T polymorphism prevalence was analyzed using …

Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …

The ATP‐binding cassette (ABC) transporter ABCB1, or P‐glycoprotein, is a transmembrane
efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 …

This work aimed to determine the frequency of 2 polymorphisms in the ABCB1 gene
(С1236T, С3435T) in healthy volunteers from the population of Tashkent region of …

Purpose: To determine the frequencies of important allelic variants and their haplotype
frequencies of the gene among Jordanian population and to compare findings with those …

eng: High blood pressure is a chronic, silent disease and an important risk factor for
developing other cardiovascular diseases. It is common for treatment with antihypertensive …

Background: The ABCB1 gene is responsible for resistance to various cytotoxic drugs. The
product of the ABCB1 gene, P-glycoprotein (P-gp), acts as a transmembrane pump and …

The most widely studied polymorphisms of the ABCB1 gene are rs1128503 (c. 1236C> T),
rs2032582 (c. 2677G> T/A), and rs1045642 (c. 3435C> T). Although variation in ABCB1 …

Limited data of ABCB1 3435C> T and 2677G> T/A SNPs and its expression in peripheral
mononuclear cells (PBMCs) with proper normalization of endogenous controls used is …

Abstract The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We
analyzed 278 healthy Brazilian individuals through PCR–RFLP to identify ABCB1 variants …