WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The pharmacokinetics of verapamil
have been assessed in a number of studies.• As a substrate of P‐glycoprotein (P‐gp) …

Aims The aim of the study was to determine whether a correlation exists between MDR1
(ABCB1) gene polymorphisms at positions 3435 (C3435T) and 2677 (G2677T (A)) and the …

ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Background: ATP-binding cassette transporter 1 (ABCB1) plays a critical role in the
development and progression of cardiovascular disease. Emerging evidence suggests that …

BACKGROUND: Genetic variations in ABCB1 gene that encodes P-glycoprotein, the main
transporter in the efflux of carbamazepine (CBZ) from the brain cells, can lead to …

Background: Rheumatoid arthritis (RA) is an inflammatory disease requiring treatment by
disease-modifying agents like methotrexate. C3435T is a single nucleotide polymorphism in …

Objectives CYP3A5 and ABCB1 are highly implicated in the pharmacokinetics and
pharmacodynamics of immunosuppressive agents, such as calcineurin inhibitors and …

Aim P-glycoprotein, the product of the ATP-binding cassette subfamily B member 1 (ABCB1)
gene (or the so-called multidrug resistance 1 gene), is an ATP-driven efflux pump …

Optimization of drug therapy many times involves circumvention of the body's defense
mechanisms. P-glycoprotein (P-gp), a member of the large adenosine triphosphate--binding …

Purpose Polymorphisms in the ABCB1 gene may influence P-glycoprotein (Pgp) expression
and/or activity. Because the population in Brazil is markedly heterogeneous, we analyzed …